T cell receptor structural repertoire database

Welcome to the T cell receptor (TCR) structural repertoire database. Here we provide an easy-to-use interface to view all experimentally determined structures of T cell receptors and their complexes. This includes complementarity determining region loops and analysis of interfaces with antigenic peptide and MHC.

We have updated the site in 2024, recent additions include:

• Class I and Class II peptide-MHC complex structures
• TCR mimic antibodies in complex with peptide-MHC
• TCR-CD3 complex structures
• TCR-peptide-MHC binding affinities available in the Class I and Class II complex tables

The major goal of this site is to enable insights into the basis of TCR structure and recognition, to assist efforts in predictive modeling of this key component of the adaptive immune response, and to facilitate rational engineering of improved and novel immunotherapeutics.